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KMID : 1038120230560060812
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Clinical Endoscopy
2023 Volume.56 No. 6 p.812 ~ p.816
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Gastric cancer presenting with ramucirumab-related gastrocolic fistula successfully managed by colonic stenting: a case report
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Hiroki Fukuya
Yoichiro Iboshi
Masafumi Wada
Yorinobu Sumida
Naohiko Harada
Makoto Nakamuta
Hiroyuki Fujii
Eikichi Ihara
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Abstract
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We report a rare case of gastric cancer presenting with a gastrocolic fistula during ramucirumab and paclitaxel combination therapy that was successfully managed with colonic stenting. A 75-year-old man was admitted to our hospital with the chief complaint of melena. Esophagogastroduodenoscopy revealed a large ulcerated tumor in the lower stomach, judged by laparoscopy as unresectable (sT4bN1M0). After four cycles of first-line chemotherapy with S-1 plus oxaliplatin, the patient showed disease progression, and second-line therapy with ramucirumab and paclitaxel was started. At the end of the third cycle, the patient had gastric antral stenosis, which necessitated the placement of a gastroduodenal stent. When the patient complained of diarrhea 10 days later, esophagogastroduodenoscopy revealed a fistula between the greater curvature of the stomach and the transverse colon. The fistula was covered by double colonic stenting, with a covered metal stent placed within an uncovered metal stent, after which leakage from the stomach to the colon stopped.
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KEYWORD
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Chemotherapy, Gastric cancer, Gastric fistula, Radiotherapy, Self expandable metal stent
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